Berberine: Ntchito, Ubwino, Zowonjezera ndi Zotsatira Zake

Berberine ali ndi mbiri yakale yogwiritsidwa ntchito m'machitidwe azachipatala, mongaAyurvedandi mankhwala aku East Asia. Ndi mankhwala okoma kwambiri omwe amachokera ku zomera zosiyanasiyana, monga hydrastis canadensis (goldenseal), coptis chinensis (coptis kapena goldenthread) ndi berberis vulgaris (barberry). Kafukufuku akuwonetsa kuti berberine ikhoza kukhala ndi antimicrobial ndi antibiotic properties, komanso zotsatira zabwino pa metabolism, koma mayesero ena azachipatala amafunika kuti atsimikizire ubwino umenewu.

Berberine athanso kukhala ndi maubwino ambiri amthupi komanso ntchito zachipatala m'chiwindi, impso, mtima ndi ubongo, zomwe zimatha kupereka chithandizo chowonjezera cha metabolic. Mwachitsanzo, berberine imayendetsa puloteni ya AMP-activated protein kinase, yomwe kafukufuku akuwonetsa kuti imathandizira kuwongolera kagayidwe, ntchito zama cell ndi kuchuluka kwa mphamvu.

Berberine imagwiritsidwa ntchito makamaka pothandizirakuchepetsa shuga m'magazi, kusintha thanzi la mtima, kuchepetsa kupsinjika kwa okosijeni ndikuchepetsa cholesterol, komanso zotsatira zake zotsutsana ndi kutsekula m'mimba, zotsutsana ndi zotupa komanso zotsutsana ndi khansa, anatero Heather Zwickey, Ph.D, pulofesa wa immunology ku National University of Natural Medicine ku Portland, Oregon.

Berberine imapezeka mu mawonekedwe a kapisozi, koma imapangidwanso ngati madontho a maso ndi ma gels osiyanasiyana otupa pakhungu, maso kapena mafupa.

Zomera ndi zitsamba zambiri zomwe zili ndi berberine zakhala zikugwiritsidwa ntchito ngati mankhwala kwa zaka masauzande ambiri, komabe kafukufuku wochulukirapo akufunika kuti amvetsetse momwe mankhwalawa amagwirira ntchito komanso zotsatira zake zanthawi yayitali. Ndizinena izi, kafukufuku akuwonetsa kuti zitha kupindulitsa thanzi la munthu m'njira zingapo.

Itha Kuthandiza Kutsitsa Shuga Wamagazi ndikupewa Kukaniza kwa insulin

Ndemanga ya 2022 muMamolekyuZimasonyeza kuti berberine ingathandizekutsitsa shuga m'magazichifukwa imachulukitsa kupanga insulini ndikuwongolera chidwi cha insulin, ngakhale kafukufuku wochulukirapo akufunika kuti mumvetsetse bwino izi[1].

Zingathandize Kuchepetsa Cholesterol

Kafukufuku akuwonetsa kuti berberine ikhoza kukhala ndi zotsatira zabwinoLDL cholesterolndi cholesterol yonse, ngakhale mayesero owonjezera azachipatala amafunikira kuti amvetsetse zomwe adanena zathanzi izi kwathunthu.

Ikhoza Kupititsa patsogolo Thanzi Lamtima

Berberine ikhoza kukhala ndi zotsatira zabwino pa minofu ya mtima, makamaka ngati ischemia (magazi osakwanira) amatha kupititsa patsogolo mphamvu za minofu ya mtima, kuchepetsa kutupa, kuchepetsa kupsinjika kwa okosijeni, kuchepetsa kuthamanga kwa magazi ndi kuwonjezeka kwa mtima.

Zitha Kukhala ndi Anti-Inflammatory Effects

Berberine ndi alkaloid yowawa yomwe imapereka zotsatira zotsutsana ndi kutupa, akutero Alicia McCubbins, dokotala wa naturopathic wokhala ku Vancouver, Washington. Izi zitha kupindulitsa njira zonse za kagayidwe kachakudya, monga zomwe zingathandizire kupewa matenda a atherosclerosis, matenda a shuga a 2, kunenepa kwambiri komanso zovuta zamtima. Berberine's anti-inflammatory properties akhala akuphunziridwa motalika, koma njira yake yogwirira ntchito sinamvekebe, kuwonetsa kufunikira kwa kafukufuku wowonjezera.

Atha Kukhala ndi Zinthu Za Antioxidant

Ndemanga ya 2018 muFrontiers mu Pharmacologyamamaliza kuti berberine antioxidant zotsatira zake n'zofanana ndi vitamini C, wamphamvu kwambiri antioxidant[2]. Zinthu monga vitamini C ndi berberine zimakhala ngati antioxidants kuti zithandizire kupewa kuwonongeka kwa ma free radicals kungayambitse maselo.

Mutha Kukhala ndi Antibacterial ndi Antimicrobial Properties

"Berberine ali ndi astringent properties ndipo amatengedwa kuti ndi mankhwala achilengedwe omwe amatha kuchotsa mabakiteriya, tizilombo toyambitsa matenda ndi bowa / candida," akugawana Dr. McCubbins. Ma antimicrobial awa angathandize kusintha zinthu zina, monga pachimakekutsekula m'mimba, kamwazi, jaundice ndi matenda a nyini, ngakhale kafukufuku wochuluka akufunika kuti atsimikizire izi. Ngati munthu akukhulupirira kuti ali ndi matenda a bakiteriya amtundu uliwonse, ayenera kukaonana ndi wothandizira zaumoyo kuti amudziwe bwino ndi kulandira chithandizo asanayambe kumwa berberine kapena china chilichonse chowonjezera.

Akhoza Kupititsa patsogolo Thanzi la M'mimba

Berberine atha kupindula ndi nkhawa zam'mimba, monga kudzimbidwa ndi kudzimbidwakutentha pamtima, malinga ndi kunena kwa Dr. McCubbins. "Ma alkaloid awa angapereke ubwino wodalirika ku mgwirizano wa m'matumbo ndi ubongo," akuwonjezera, kutsindika kufunika kwa mgwirizano pakati pa chimbudzi, maganizo ndi thanzi labwino.

Akhoza Kuthandizira Kuchepetsa Kuwonda ndi Kuwongolera Kulemera

Berberine atha kuthandizira kuchepetsa kusungidwa kwamafuta ndi shuga mwa kukonza kagayidwe kachakudya, monga kuwonongeka kwa lipids (mafuta) ndi shuga, kafukufuku akuwonetsa. Zotsatira zabwino za Berberines pamatumbo a microbiome zitha kukhalanso gawo lofunikira pakuwongolera kulemera.

Zitha Kupititsa patsogolo Zizindikiro za Polycystic Ovarian Syndrome (PCOS) ndi Ovulation

Malinga ndi ndemanga muMamolekyukumwa mamiligalamu 1,500 a berberine patsiku kwa miyezi itatu kumachepetsa kuchuluka kwa testosterone mwa amayi omwePCOS[3]. Mkhalidwewu ukhoza kukhala ndi kuchuluka kwa mahomoni oberekera osadziwika bwino ndipo kumabweretsa kusalinganika kosiyanasiyana, zomwe zimadzetsa zovuta monga zotupa zazing'ono zam'mimba kapena msambo. Akatswiri amakhulupiliranso kuti berberine imathandizira kukana insulini, yomwe ndi gawo lodziwika bwino la PCOS. Komabe, ofufuza akusonyeza kuti mayesero ena azachipatala amafunika kuti atsimikizire zotsatira za berberine, kuphatikizapo kutalika kwa mankhwala ndi mankhwala ochiritsira.

 

Momwe Mungatengere Berberine?

Zowonjezerapo za Berberine zimapezeka mu kapisozi, piritsi kapena mawonekedwe a tincture, kulola kuti mulingo wolondola komanso wosavuta kumwa. Makapisozi angakhale abwino kwa ogula ambiri chifukwa cha kukoma kwake kowawa kwambiri, akufotokoza Dr. McCubbins. "Berberine nthawi zambiri amatengedwa ngati chimbudzi cham'mimba mphindi 5 mpaka 30 musanadye. Berberine mwachibadwa ndi owawa zomwe zimalimbikitsa madzi am'mimba kuti azigwira ntchito bwino m'mimba," akupitiriza.

Mlingo wa Berberine

Anthu ayenera kuonana ndi dokotala kapena katswiri wa zitsamba kuti akambirane za mlingo wolondola (omwe suli wovomerezeka), ndi kuwerenga malangizo a wopanga, akutero Dr. Zwickey. “Kaŵirikaŵiri amaonedwa kuti ndi abwino pa mlingo [wosapitirira] 2 magalamu. Kuti [apeze zotsatira zabwino], munthu angafune kugwiritsa ntchito 1 gramu (1000 milligrams) patsiku. Zambiri zowonjezera [zimakhala] mamiligalamu 500 pa kapisozi, kotero wina angafune kumwa [osachepera awiri] makapisozi patsiku,” akupitiriza.

Mlingo wa Berberine ungadalire zolinga za thanzi la munthu. Ponena za shuga wamagazi, kuwunika mwadongosolo kwa 2019 ndi kusanthula meta muEndocrine Journaladapezeka kuti akumwa zosakwana magalamu a 2 a berberine patsiku kwa miyezi itatu adakhudzanso kuchuluka kwa shuga m'magazi mwa omwe ali ndi matenda amtundu wa 2.[4].

Pakadali pano, kuwunikanso komwe kulipo kafukufuku muThandizo Lothandizira mu Clinical Practiceadawunika kuyankha kwa mlingo wa berberine Tingafinye kwa anthu onenepa ndi kufunafuna kasamalidwe kulemera, anapeza kuti Mlingo wa 500 milligrams kutengedwa katatu patsiku kumabweretsa kuchepabody mass index (BMI), kuzungulira kwa chiuno ndi kulemera kwa thupi[5].

Zotsatira za Berberine

Mankhwala a Berberine amatha kukhala ndi zotsatira zina, kuphatikizapo kutsekula m'mimba, kupweteka kwa m'mimba ndi mutu, akutero Dr. McCubbins.

"Berberine ikukwera kutchuka ndikugulitsidwa kwambiri kwa anthu ochepetsa thupi," akupitiliza. "Khalani osamala ndipo funsani dokotala wa naturopathic za [za] kugwiritsa ntchito mankhwala [a berberine musanamwe]."

Ngakhale kuti berberine nthawi zambiri imalekerera bwino, ingayambitse kupweteka kwa m'mimba ndi kusokonezeka, kudzimbidwa, kutsekula m'mimba, flatulence, nseru ndi kusanza, akuwonjezera Dr. Zwickey.

Kodi Berberine Ndi Yotetezeka?

Chodetsa nkhaŵa chachikulu cha chitetezo cha berberine ndikuti chingagwirizane ndi mankhwala angapo, akutero Dr. Zwickey. Kulumikizana koopsa kwambiri ndi cyclosporine, mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pambuyo poika chiwalo ndikuthandizira kuthana ndi vuto la autoimmune monga.nyamakazi, monga berberine imawonjezera kuchuluka kwa cyclosporine m'magazi, akufotokoza.

Mosasamala kanthu kuti munthu amatenga berberine ngati chowonjezera chodziyimira pawokha kapena mumtundu wonse wa zitsamba, ndikofunikira kutsatira malangizo omwe amaperekedwa ndi wopanga mankhwala kapena akatswiri azaumoyo. Berberine ndi contraindicated kwa ana, komanso anthu apakati ndi kuyamwitsa, anati Dr. Zwickey.

Zomwe Muyenera Kuziganizira Pogula Berberine?

Chifukwa opanga ambiri amayeretsa berberine kuchokera ku chomera, kuyezetsa ma labotale a chipani chachitatu kuti adziwe berberine, mphamvu, khalidwe ndi chiyero ndizofunikira, akutero Dr. Zwickey. "Mmodzi ayenera kukhala wosamala kwambiri zakupeza ndalama zowonjezera kuchokera ku kampani yowonjezera ya dokotala kuti atsimikizire kuyesa kwa chipani chachitatu kuchokera ku makampani odziwika bwino ndi chitsimikizo cha khalidwe la [malamulo] abwino kwambiri," akuwonjezera Dr. McCubbins.

M'pofunikanso kuonetsetsa kuti berberine ndi sourced zisathe, malinga Dr. McCubbins. "Goldenseal, ngakhale gwero labwino kwambiri la berberine, ili pachiwopsezo. Makampani odziwika bwino owonjezera akudziwa [nkhani] iyi, "akufotokoza motero. Zolemba zambiri zowonjezera zimatanthauzira kuchokera ku zitsamba zomwe berberine imachotsedwa.

Popeza berberine ikusowa maphunziro a chitetezo cha nthawi yayitali, munthu ayenera kukaonana ndi wothandizira zaumoyo asanawonjezere berberine ku regimen yawo yowonjezera kuti atsimikizire kuti ndiyoyenera komanso yotetezeka pa zosowa zawo zapadera. Kuti mudziwe zambiri za ubwino wa berberine pa thanzi, lankhulani ndi dokotala wa naturopathic, herbalist wovomerezeka kapena acupuncturist.